Protein Modification Reagents
Medchemexpress LLC Methyl-PEG4 N-hydroxysuccinimide ester | 622405-78-1 | MFCD11041112 | 95.0% | 333.33 | C14H23NO8 | 1G
M-PEG4-NHS ester is a methyl-terminated polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester. It is intended for bioconjugation and medicinal chemistry applications, including PROTAC synthesis and amine labeling, where an amine-reactive spacer that improves solubility and enables stable amide bond formation is required.
- Provides an NHS ester for efficient coupling to primary amines.
- Methyl-terminated PEG4 spacer improves solubility and reduces steric hindrance.
- Molecular weight 333.33 and formula C14H23NO8.
- Typical purity 95.0% suitable for synthetic applications.
- Available in multiple pack sizes, including 1 g.
Medchemexpress LLC m-PEG6-CH2CH2COOH | 874208-91-0 | >=95.0% | 368.42 g/mol | C16H32O9 | 500 MG
m-PEG6-CH2CH2COOH is a polyethylene glycol (PEG)-based PROTAC linker terminated with a carboxylic acid. It provides a six-unit PEG spacer for flexible linkage in conjugation chemistry and is supplied as a solid for synthetic use. Typical quality: ≥95.0% purity; molecular weight 368.42 g/mol; formula C16H32O9; CAS 874208-91-0.
- Peg6 spacer with terminal carboxylic acid for conjugation.
- Suitable for use as a PROTAC or linker building block in medicinal chemistry.
- Available in multiple pack sizes, including 500 MG.
- High purity for synthetic applications (≥95.0%).
- Solid form with defined molecular weight (368.42 g/mol).
eMolecules 596820-83-6 | Medchem Express | Biotin-PEG2-NHS ester | 25mg | 761506345 | HY-140888 | 500.57 | C21H32N4O8S
Medchem Express | Biotin-PEG2-NHS ester | 25mg | 761506345 | HY-140888 | 596820-83-6 | 500.570 | C21H32N4O8S
BEZWADA BIOMEDICAL LLC PEG Methacrylate, MW 10,000, 5.0 GM
Acrylate/methacrylate end functionalization enables crosslinking. Polymers used in drug delivery and various biomedical applications
Cayman Chemical BIotIn-PEG3-azIde 25mg
A PEGylated version of biotin-azide that is more hydrophilic; can be used to label terminal alkynes via copper-catalyzed click reactions or copper-free click reactions with cyclooctynes; used to covalently tag proteins in combination with other tags
Medchemexpress LLC HY-103606 100mg Medchemexpress, (S,R,S)-AHPC-PEG6-C4-Cl CAS:1835705-59-3 Purity:>98%
Medchemexpress, HY-103606 100mg (S,R,S)-AHPC-PEG6-C4-Cl CAS:1835705-59-3 (S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Dbco-peg2-val-cit-pab-mmae | 2845934-59-8 | 99.3% | 1569.92 g/mol | C84H120N12O17 | 25 MG
A cleavable ADC linker composed of a DBCO reactive handle, a PEG2 spacer, a cathepsin-cleavable valine-citrulline dipeptide with a para-aminobenzyl (PAB) self-immolative spacer, and the cytotoxic MMAE payload. Designed for conjugation via strain-promoted alkyne-azide cycloaddition (SPAAC) to form antibody-drug conjugates.
- High purity suitable for conjugation reactions.
- Cleavable val-cit dipeptide enables payload release in lysosomes.
- Dbco moiety supports copper-free click conjugation (SPAAC).
- Peg2 spacer improves solubility and linker flexibility.
- Available in small mg-scale quantities for synthesis and development.
Medchemexpress LLC Propargyl-O-C1-amido-PEG4-C2-NHS ester | 2101206-92-0 | 95.0% | 458.46 g/mol | C20H30N2O10 | 50 MG
Propargyl-O-C1-amido-PEG4-C2-NHS ester is a non-cleavable, four-unit PEG linker that contains a propargyl (alkyne) functional group and an N-hydroxysuccinimide (NHS) ester. It is used for bioconjugation workflows, including antibody-drug conjugation and click chemistry applications.
- Non-cleavable 4-unit PEG linker.
- Alkyne functional handle for copper-catalyzed azide-alkyne cycloaddition.
- Reactive NHS ester for efficient amine coupling.
- Purity typically 95.0%.
- Available in multiple pack sizes, including 50 MG.
![eMolecules Broadpharm / N-(Acid-PEG36-PEG3-)-N-bis(PEG3-biotin) / 25mg / 761705542 / BP-28868 / 98.000 / / [null] / 2681.280 / C120H230N8O52S2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502474111.JPG-250.jpg)
eMolecules Broadpharm / N-(Acid-PEG36-PEG3-)-N-bis(PEG3-biotin) / 25mg / 761705542 / BP-28868 / 98.000 / / [null] / 2681.280 / C120H230N8O52S2
Broadpharm / N-(Acid-PEG36-PEG3-)-N-bis(PEG3-biotin) / 25mg / 761705542 / BP-28868 / 98.000 / / [null] / 2681.280 / C120H230N8O52S2
Medchemexpress LLC Azido-PEG20-alcohol | 1637297-21-2 | >98% | C40H81N3O20 | 100 MG
Azido-PEG20-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a click chemistry reagent containing an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with alkyne groups
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
Medchemexpress LLC Tos-PEG4-acid | 1453117-42-4 | 97.2% | 50 MG
Tos-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound facilitates the degradation of target proteins by exploiting the intracellular ubiquitin-proteasome system.
- Peg-based PROTAC linker
- Utilized in PROTAC synthesis
- Facilitates protein degradation
- Selectively targets proteins via ubiquitin-proteasome system
![eMolecules (S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183626.JPG-250.jpg)
eMolecules (S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592
(S, R, S)-AHPC-PEG8-NHS ester | Broadpharm |980.140 | C46H69N5O16S | 98.000 | Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O)C(C)(C)C)cc1 | 250mg | 573896592